Perfusionists are highly skilled professionals who operate life-support equipment such as heart-lung machines, intra-aortic balloon pumps and ventricular assist devices during open-heart surgery. Integral members of the cardiovascular surgical team, perfusionists are present in the operating room when it is necessary to support or replace a patient’s cardiopulmonary and circulatory functions. Perfusionists also provide services for venovenous bypass for liver transplantation, isolated limb or organ chemotherapy perfusion, cardiopulmonary bypass-supported cardiac catheterization procedure; extracorporeal membrane oxygenation and blood salvaging for orthopedic or general surgery procedures. The 3+2 program between Benedictine University’s Clinical Life Science undergraduate program and Rush University’s master’s program in Perfusion Technology combines didactic, diverse clinical experience and research in adult and pediatric settings. The program uniquely features an emphasis on management techniques relative to the hospital perfusion department. Upon successful completion of the certification exam, perfusionists are certified as clinical perfusionists by the American Board of Cardiovascular Perfusion.