Genentech: Associate Scientist-DMPK Bioanalytical/Mass Spectrometry
We are seeking an exceptional individual for an Associate Scientist position within the small molecule bioanalytical group of DMPK Department at Genentech. The successful candidate will have strong background in Bioanalytical Mass spectrometry (LC-MS/MS and LC-HRMS) with hands on experience and proven ability to independently design, develop and routinely employ bioanalytical methods for the quantitative and qualitative analysis of endogenous small molecule metabolites (biomarkers), new chemical entities and their metabolites in various biological matrices. Candidates should also have a very good understanding of various small molecule metabolomics workflows, instrumentation and experiment design. This role also requires a good understanding of preclinical and clinical ADME, endogenous metabolic pathways to work collaboratively with teams from research to drug discovery and development. The candidate will work as a member of the metabolomics/bioanalytical group and will be responsible for method development, sample preparation (LLE, SPE, and PP) and data acquisition on various platforms such as QTRAPs, triple-quadrupole instruments, high-resolution mass spectrometers (QTOF, Orbitrap QE series), and data processing using Xcalibur, Compound Discoverer, Tracefinder, Analyst/Multiquant, and XCMS+. The candidate should be able to assist in troubleshooting when instrument or assay problems arise. Other responsibilities will include metabolomics data visualization and statistical analysis, electronic laboratory notebook keeping and communication of results to project teams.
Researcher / analyst
1 DNA Way, CA 94080
South San Francisco , United States