Senior Scientist, Synthetic Biology

Allogene Therapeutics

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Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer. Led by a world-class management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell therapy candidates with the goal of delivering readily available cell therapy faster, more reliably and at greater scale to more patients.

AlloCAR T™ cell therapies are engineered from cells of healthy donors, which is intended to allow for creation of inventory for on demand use in patients. This approach is designed to eliminate the need to create personalized therapy from a patient’s own cells, simplify manufacturing, and reduce the time patients must wait for CAR T cell treatment. The Allogene portfolio includes rights to 16 pre-clinical CAR T cell therapy targets and UCART19, an AlloCAR T™ therapy candidate currently in Phase 1 sponsored by Servier for the treatment of relapsed/refractory acute lymphoblastic leukemia (ALL). For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.

Job Description:

Allogene Therapeutics is seeking a highly motivated Senior Scientist in Synthetic Biology to design and evaluate novel synthetic proteins that improve the efficacy and safety of allogeneic CAR T cells. The successful candidate will report directly to the Head of Protein Engineering and be responsible for developing these technologies in close collaboration with an exceptional and multidisciplinary team of immunologists, biologists and protein engineers.  The ideal candidate will have a practical understanding of synthetic biology or protein engineering and a demonstrated track record of applying this knowledge to solve biological problems. They are an individual who is interested in working in a fast-paced, dynamic and highly collaborative start-up environment with a willingness to take on new challenges.

Responsibilities include, but are not limited to:

  • Identify desirable CAR T cell attributes in close collaboration with a multidisciplinary team
  • Design then validate novel protein constructs in the context of CAR T cells using in vitro assays then work closely with colleagues to test them using in vivo models
  • Contribute to a collaborative group effort for advancing allogeneic CAR T cell therapies into solid tumors
  • Stay abreast of the latest scientific and technology advancements in the field
  • Train and mentor other scientists and perform other duties as required
  • Present at group meetings and project team meetings
  • Opportunity to publish novel scientific findings and attend or present at scientific meetings

Requirements:

  • PhD with a strong foundation in cellular and molecular biology and less than 5 years of post-graduate experience acquired in either an academic or industry setting
  • Expertise in synthetic biology or more traditional protein engineering
  • Experience with de novo protein design or designing chimeric proteins with novel biological properties is preferred
  • Experience with retroviral/lentiviral transduction of human T cells is desired
  • Understanding of signal transduction especially as it pertains to immune cells is beneficial
  • Desire to expand knowledge and technical expertise associated with CAR T cells
  • Meticulous and highly organized as it pertains to experimental design, bench-work, record keeping and data analysis
  • Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines
  • Strong interpersonal skills including relationship building, conflict resolution, and verbal and written communication are essential in this collaborative work environment
  • Ability to effectively work in a fast-paced, start-up environment, while dealing with ambiguity
  • Candidates must be authorized to work in the U.S

As an equal opportunity employer, Allogene Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact the careers email at www.allogene.com for assistance.

For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.

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More Information

Type

Researcher / analyst

South%20San%20Francisco%2C%20United%20States

South San Francisco , United States

Location

United States

South San Francisco

Type

Researcher / analyst

South%20San%20Francisco%2C%20United%20States