ADME Lead Investigator – Pharmacokinetic Scientist | Novartis

Novartis Diagnostics
Posted on

Type

Researcher / analyst

Job Description

One ADME Investigator is all it takes to contribute to advancing new therapies to improve patients’ lives. At the Novartis Institutes for Biomedical Research (NIBR), we are reimagining medicine using science-based innovation. PK Sciences is a global organization of about 300 associates, situated within Translational Medicine (TM), the clinical research arm of NIBR. PK Sciences plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, bridging drug discovery and clinical application. PK Science is an enterprise organization, working across both NIBR and the Global Drug Development (GDD) organizations to advance the scientific knowledge of pharmacokinetics, metabolism and clinical pharmacology.The ADME In Vitro team is looking for an ADME Lead Investigator with a dual role of laboratory work coordination both internally and with external partners and project support. Responsibilities include identification of enzymes and transporters involved in the disposition of drug candidates and assessment of absorption and elimination in humans. The candidate will work in a team of skilled scientists and must have a strong scientific knowledge of ADME InVitro assays commonly used from early discovery until registration with a proven track record of relevant scientific publications and presentations at scientific conferences. What you’ll be doingProject support includes input to the design and monitoring of studies required to enable testing in humans, including compilation of technical documents, study reports, and authoring documents in support of regulatory submissions.Laboratory work includes developing new in vitro assays/models with improved predictive power and adapt the assay portfolio to the evolving needs of the organization. Other activities include the development of internal and external collaborations to address specific project needs and the active participation in multi-disciplinary project teams. The selected candidate shall be able to cover various aspects of drug disposition and be capable of providing expert technical/scientific assistance on projects as well as strategic input. Working in a team across geographies, mentoring less experienced associates and continue to develop the team skills to maintain competitive edge. Good oral and written communication skills as well as a good scientific network are essential. Your responsibilities will include, but not limited to:• Identify transporters and enzymes involved in the disposition/clearance of drug candidates or drug classes and assessment of the potential for drug-drug interactions in humans. • Actively participate in multi-disciplinary project teams, and compilation of technical documents, method reports, compound-specific study reports, and documents in support of regulatory submissions. • Work independently, have a strong scientific knowledge of drug transport and metabolism and capable of providing expert technical/scientific assistance on projects. The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements

What you will bring to the role: The position requires a Ph.D. degree in Biochemistry, Biology, Chemistry, Bioengineering or equivalent, with a demonstrated experience in the field of ADME InVitro supported by drug development achievements, a strong scientific record in the literature and experience in training of junior associates. The position requires a strong background and understanding of drug metabolism/transport interplay and pharmacokinetics principles. Optional working knowledge of LC-MS/MS analytics, lab automation and/or HPLC with radioactivity-based detection is preferred. A very good working knowledge of general laboratory techniques used in the ADME In Vitro field. Good communication and negotiation skills across multi-disciplinary global research teams, both oral and written.What Novartis can offer you?Yes, we offer exceptional benefits and competitive salaries. However, we can offer more. Here you will:• Work with the latest technologies• We focus on personal and team achievements by taking smart risks while maintaining high ethical standards.• Innovation is at the heart of what we do. We encourage people to experiment and take smart risks. Our aim is to foster creative thinking that leads to practical solutions to healthcare and business challenges.Why consider Novartis? Transformative medicines need transformative thinking. We believe the answers are found when curious, courageous, and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges. We are Novartis. Join us and help us reimagine medicine.

More Information

Posted on

Type

Researcher / analyst

Cambridge%2C%20United%20States

Cambridge , United States